SCIENCE

The Science Behind KNOWHEN® Proven Saliva-based Technology

KNOWHEN® Advanced Saliva Ovulation Test Kit with Fertility Monitor App Identifies five (5) most fertile days with 98.9% accuracy proven by U.S. Clinical Studies. Millions of women have infertility issues mostly caused by ovulation problems and millions more of childbearing age need to know when they ovulate.

A Historical Overview

The journey into understanding saliva’s role in fertility tracking began in 1945, when Dr. George papnicolau first noted microscopic  crystal formations in cervical fluid. the phenomenon, known as ferning, is key to identifying  fertile wisdom  in the menstural cycle. 

Pioneering Research

In 1969, Dr. Biel Cassals, a Spanish gynecologist, extended this research to saliva. His groundbreaking presentation to the Barcelona Medical Board established that hormonal changes during the menstrual cycle influence the crystallization of saliva, which mimics the arborization effect seen in cervical mucus.

Hormonal Connections and Fertility

Estrogen, a hormone closely linked to fertility, modulates the salinity of saliva. As ovulation approaches and estrogen levels surge, so does the salinity in saliva. This increase causes saliva to crystallize in patterns similar to those in cervical mucus, which are detectable under a microscope.

FDA Approval and Clinical Validation

In 2009, the KNOWHEN® Advanced Saliva Ovulation Test received FDA clearance. Conducted by Dr. Hugh Melnick at the Manhattan Fertility Center, U.S. clinical studies affirmed the test's 98.9% accuracy. These studies demonstrated a significant correlation between the ferning patterns in saliva and actual ovulation, confirmed through sonographic examinations.

Nature cleverly preserves in a Woman’s SALIVA the answer to very important questions: “Am I ovulating?” and “When is the best time for me to conceive?”

Checking saliva daily will unlock the secret of a woman’s unique ovulation cycle and answer the most important question…”Could I get pregnant today?“

Researchers have studied the phenomenon of ferning in cervical fluid since 1945, when Papanicolau observed mi- croscopic crystal formations in cervical fluid (mucus).

In 1969, Dr. Biel Cassals, a Spanish gynecologist, studied the crystallization of saliva. His presentation to the Barcelona Medical Board proved a relationship between hormonal changes during the female menstrual cycle and the crystallization of saliva, indicating ferning saliva is virtually identical in appearance to the arborization effect of cervical fluid.

The hormone estrogen links saliva patterns to a woman’s fertility. As ovulation nears, estrogen increases and causes the body’s sodium levels to rise increasing the salinity of a woman’s saliva. Near ovulation the higher salt content causes the dried saliva to form crystallization patterns as seen under microscope. Both saliva and cervical mucus have shown these patterns.

KNOWHEN®

Teach her to easily collect her unique ovulation cycle information daily so Advanced Saliva Ovulation Test Kit with Fertility Monitor App

Every woman can know when she’s ovulating

KNOWHEN® Advanced Saliva Ovulation Test Kit with Fertility Monitor App

Saliva Ferns the Same Way as Cervical Mucus Indicating Ovulation

Nature cleverly preserves in a Woman’s SALIVA the answer to very important questions: “Am I ovulating?” and “When is the best time for me to conceive?

Checking saliva daily will unlock the secret of a woman’s unique ovulation cycle and answer the most important question…”Could I get pregnant today?
Researchers have studied the phenomenon of ferning in cervical fluid since 1945, when Papanicolau observed microscopic crystal formations in cervical fluid (mucus).

In 1969, Dr. Biel Cassals, a Spanish gynecologist, studied the crystallization of saliva. His presentation to the Barcelona Medical Board proved a relationship between hormonal changes during the female menstrual cycle and the crystallization of saliva, indicating ferning saliva is virtually identical in appearance to the arborization effect of cervical fluid.

The hormone estrogen links saliva patterns to a woman’s fertility. As ovulation nears, estrogen increases and causes the body’s sodium levels to rise increasing the salinity of a woman’s saliva. Near ovulation the higher salt content causes the dried saliva to form crystallization patterns as seen under microscope. Both saliva and cervical mucus have shown these patterns.

In 2003, KNOWHEN® Advanced Saliva Ovulation Test was cleared and registered by FDA. U.S. clinical studies proved KNOWHEN® to be 98.9% accurate. HiLin Life Products, Inc. is globally recognized as a leader in Fertility Tests and marketing research for women’s reproductive health.

Saliva Ferning Gives a Greater Planning “Window” to Get Pregnant — 5 Fertile Days

Saliva testing measures a far more gradual increase of estrogen that occurs prior to or during ovulation, and thus gives the user a greater planning “window.”

The KNOWHEN® Advanced Saliva Ovulation Test is a salivabased method proven to determine a woman’s five (5) most fertile days during her ovulation cycle — more days than any other ovulation test. In addition, fertility drugs and medications influence the LH levels in urine tests and thus can invalidate urine ovulation test results. KNOWHEN® is chemical-free and not affected by fertility drugs and medication.

How it works

KNOWHEN® ADVANTAGES VS URINE STRIPS

KNOWHEN® s more than an ovulation test for women, KNOWHEN®’s all about her reproductive health

KNOWHEN® Vs Others

KNOWHEN®

URINE STRIPS

BASAL TEMPERATURE

ORAL STRIPS MONTHLY $22

INTERNET KNOCK-OFFS

Knowledge is Power.

“We are transforming the lives of women worldwide who want to manage their fertility. We are finally giving hope to so many women who thought they couldn’t have a family.”

Helen Denise, Miss Ovulation

KNOWHEN®

Advanced Saliva Ovulation Test Kit with Fertility Monitor App The most accurate ovulation test on the market — the ONLY U.S. Clinically Tested

Accurate ovulation test on the market — the ONLY U.S. Clinically Tested
and FDA cleared saliva ovulation test with 98.9% accuracy.
Show women exactly when they’re ovulating.

Millions of women have infertility issues mostly caused by ovulation problems
and millions more of childbearing age need to know when they ovulate.

KNOWHEN® Unlocks the Secret to Get Pregnant

Knowing her time of ovulation is the most effective way to increase the chance of conception. The KNOWHEN® Advanced Saliva Ovulation Test Kit shows women her five (5) most fertile days of ovulation in minutes so she can get pregnant faster, avoid pregnancy, or monitor her regular cycles. Use the convenient KNOWHEN®
Fertility Monitor App to track cycle results.
Use for conception and natural family planning.

Why KNOWHEN® is Better

Rated Best Ovulation Predictor Kit for the Past 3 Years

KNOWHEN® is for Women

KNOWHEN® Ovulation Kit includes:

Use KNOWHEN® for Conception and In Addition to Contraception Methods

Whether she’s trying to get pregnant or avoid pregnancy, KNOWHEN® will indicate the five (5) most fertile days a woman is most likely to get pregnant. Help women understand their fertility by starting a simple habit of taking a daily saliva ovulation test at home to collect their unique and critical ovulation cycle information to manage women’s reproductive and sexual health.

Every woman needs to know her five (5) most fertile days with 98.9% accuracy

Saliva Ferning Gives a Greater Planning “Window” to Get Pregnant — 5 Fertile Days

Saliva testing measures a far more gradual increase of estrogen that occurs prior to or during ovulation, and thus gives the user a greater planning “window.”

The KNOWHEN® Advanced Saliva Ovulation Test is a saliva-based method proven to determine a woman’s five (5) most fertile days during her ovulation cycle — more days than any other ovulation test. In addition, fertility drugs and medications influence the LH levels in urine tests and thus can invalid date urine ovulation test results. KNOWHEN® is chemical-free and not affected by fertility drugs and medication.

Our Happy Mothers

Excellent product! I am using it along with the Billings ovulation method and it is just a perfect combination for me since the Billings method tells me my fertile days and this one not only knows when I am fertile but also when I am ovulating!

Maria Palito

Happy mother from LA

 The KNOWHEN® saliva test has been a fantastic addition in our quest for pregnancy. It is so empowering to have a visual component to see your own hormone changes and predict fertility. It is so much cleaner to use and less wasteful than the plastic monitors and plastic urine sticks.

Willie Ryan

Happy mother from California

 This product empowers women to have reliable information regarding their fertility. Knowledge is power and this gives reliable information to all who use it. I give it to my family and friends who want to know when they are fertile to conceive and those who want a non-invasive and drug-free form of birth control.

Judy L. Davis

Happy mother from Newyork